| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271043 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
An efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from the commercially available pentane1,5-diol. A Shi epoxidation and Pd(0)-mediated nitrogen substitution with double inversion established the correct configuration of the balanol precursor 3.
Graphical abstractAn efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from the commercially available pentane1,5-diol. A Shi epoxidation and a Pd(0)-mediated nitrogen substitution with double inversion are the key steps to establish the correct configuration of the balanol precursor 3.Download full-size image
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Organic Chemistry
Authors
Srinivasarao Yaragorla, Ramaiah Muthyala,