| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271049 | Tetrahedron Letters | 2010 | 6 Pages |
Abstract
Fe(Cp)2PF6 (5 mol %) efficiently catalyzed Mannich reaction of aldehydes, anilines, and ketones under solvent-free condition to give β-amino-ketones in high yield (up to 94%) within 30 min with anti-isomer in excess. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones.
Graphical abstractFe(Cp)2PF6 catalyzed Mannich reaction of aldehydes, anilines, and ketones under solvent-free condition to give β-amino-ketones in high yield (up to 94%) within 30 min with anti-isomer in excessDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rukhsana I. Kureshy, Santosh Agrawal, S. Saravanan, Noor-ul H. Khan, Arpan K. Shah, Sayed H.R. Abdi, Hari C. Bajaj, E. Suresh,