| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271088 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A convenient synthesis of 1-haloethenamides has been achieved by utilizing halotrimethylsilane (TMSX, XÂ =Â Cl, Br, I) and water. Halotrimethylsilane in 1Â M CH2Cl2 solution functions as a halogen source of the in situ generated HX, and the HX added to the terminal triple bonds of ynamides in Markovnikov fashion.
Graphical abstractSimple synthesis of 1-haloethenamides was successfully achieved through the addition of in situ generated HX.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuhiro Ohashi, Shigenori Mihara, Akihiro H. Sato, Masataka Ide, Tetsuo Iwasawa,