| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271093 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
The synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl] coumarins has been achieved from the reactions of 4-hydroxycoumarin with 2-(6-substituted-9H-purin-9-yl)acetaldehydes in DMF under heating. The new compounds showed significant lipoxygenase inhibitory activity (e.g., 6a: IC50 = 6.25 μM).
Graphical abstractThe synthesized compounds act as lipoxygenase inhibitors.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors](/preview/png/5271093.png "First Page Preview: Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors")
Authors
Michael G. Kallitsakis, Dimitra J. Hadjipavlou-Litina, Aikaterini Peperidou, Konstantinos E. Litinas,