Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271095 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
â¢It is a three-component, four center Ugi reaction.â¢It is very useful to technique to construct eight-membered pyrrolo[1,2-d][1,4]diazacines.â¢It involves a bifunctional amine tethered carboxylic acid based 3CC reaction.â¢It provides an easy access to generate combinatorial libraries of pyrrolo[1,2-d][1,4]diazacines for drug discovery.
A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5-phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazacine-5(6H)-yl)-2-phenylacetamides in moderate to good yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
P. Lakshmi Reddy, D. Ashok Kumar, M. Lakshmi Devi, T. Veera Reddy, B.V. Subba Reddy, R. Narender,