| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271106 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
The base-catalyzed reaction between isatins and N-Boc-3-pyrrolin-2-one yields Morita-Baylis-Hillman (MBH) adducts instead of the expected aldol products in good to high yields (up to 97%). Various organic and inorganic bases are efficient catalysts for this reaction. Our study excluded the Morita-Baylis-Hillman mechanism for the formation of the MBH-type products. The MBH products are most likely formed as a result of the subsequent isomerization of the original aldol products between isatins and N-Boc-3-pyrrolin-2-one.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Naresh Ramireddy, John C.-G. Zhao,