Article ID Journal Published Year Pages File Type
5271142 Tetrahedron Letters 2010 5 Pages PDF
Abstract

The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.

Graphical abstractThe utility of a bench-stable azido-boronate motif as a useful modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry