Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271142 | Tetrahedron Letters | 2010 | 5 Pages |
Abstract
The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.
Graphical abstractThe utility of a bench-stable azido-boronate motif as a useful modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide
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