Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271150 | Tetrahedron Letters | 2010 | 7 Pages |
Abstract
The heterogeneous solid catalyst, mercaptopropylsilica (MPS), has been prepared by a modified procedure in water and its structure confirmed by solid state carbon-13 CP-MAS NMR spectrum. This catalyst has been efficiently utilized for the synthesis of a wide variety of tri-, tetrasubstituted imidazoles and their bis-analogues at room temperature. The protocol was further explored for the synthesis of the drug trifenagrel.
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Authors
Chhanda Mukhopadhyay, Pradip Kumar Tapaswi, Michael G.B. Drew,