| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271215 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
CAL-B (Candida antarctica lipase B) immobilized on an acrylic resin (Novozyme® 435) smoothly catalyzes the aminolysis of methyl esters with propargyl amine furnishing propargyl amides. In the same reaction vessel these propargyl derivatives are consecutively transformed into amide ligated 1,2,3-triazoles in a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction in good to excellent yields.
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Related Topics
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Organic Chemistry
Authors
Sidra Hassan, Roxanne Tschersich, Thomas J.J. Müller,