Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271222 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
Three structurally interesting new diterpenoids, phyllanflexoids A-C (1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 μM, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jian-Qiang Zhao, Jun-Jiang Lv, Yan-Ming Wang, Min Xu, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Yi-Fei Wang, Ying-Jun Zhang,