| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271362 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN2 alkylation/Thorpe-Ziegler cyclization/regio-selective elimination of a -COR group, affording the desired products in moderate to good yields. The sequence of the leaving reactivity of -COR groups was determined and a possible mechanism was proposed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laichun Luo, Lanlan Meng, Qi Sun, Zemei Ge, Runtao Li,