Silica-bonded N-propyl sulfamic acid as an efficient catalyst for the formylation and acetylation of alcohols and amines under heterogeneous conditions

A simple and efficient procedure for the preparation of silica-bonded N-propyl sulfamic acid (SBNPSA) by the reaction of 3-aminopropylsilica (1) and chlorosulfonic acid in chloroform is described. This solid acid is employed as a new catalyst for the formylation of alcohols and amines with ethyl formate under mild and heterogeneous conditions at room temperature with good to excellent yields. Also, SBNPSA catalyzed acetylation of various alcohols and amines with acetic anhydride at room temperature.

Graphical abstractSilica-bonded N-propyl sulfamic acid (SBNPSA) was prepared by the reaction of 3-aminopropylsilica and chlorosulfonic acid in chloroform. This solid acid is employed as a catalyst for the formylation of alcohols and amines with ethyl formate at room temperature. Also, SBNPSA catalyzed acetylation of alcohols and amines with acetic anhydride at room temperature.Download full-size image