Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271488 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A new synthetic approach to the selective estrogen agonist 1 is described. The key steps in the route are a phosphine catalyzed 2+3 cycloaddition between an indanone enone and allenyl methyl ketone, and an unusual Robinson annulation to afford a bicylco[3.2.1]octane. The potential benefits of the new route are discussed along with efforts to render the approach asymmetric.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Debra J. Wallace, Robert A. Reamer,