| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271585 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
We report a facile alkylation-cyclization reaction involving the isoindolinone C3 position, which resulted in tricyclic derivatives 2 and 10 in 48% and 32% yields, respectively. These novel compounds possess potent urotensin-II receptor antagonist activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Diane K. Luci, Edward C. Lawson, Shyamali Ghosh, William A. Kinney, Charles E. Smith, Jenson Qi, Yuanping Wang, Lisa K. Minor, Bruce E. Maryanoff,