| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271589 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
We report effective preparations of the O-aryl glucuronide 2 and glucoside 4, as well as the O-acyl glucuronide 3, of the immunosuppressant agent mycophenolic acid 1. Heavy metals are avoided in the preparations of 2 and 4 and a careful optimisation of the synthesis of 3 is detailed. Finally we confirm the value of synthetic 3 by comparing its reactivity with that of a biosynthesised sample against a known target protein.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amy E. Jones, Helen K. Wilson, Paul Meath, Xiaoli Meng, David W. Holt, Atholl Johnston, Michael Oellerich, Victor W. Armstrong, Andrew V. Stachulski,