| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271597 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald protocol are the key elements of the synthetic approach. The hydroxy thiophene-containing compounds displayed good binding inhibitions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianhua Chao, Arthur G. Taveras, Cynthia J. Aki,