| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271695 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A mechanochemical oxidation of methoxylated aromatic chemicals is described, providing an example of a very different selectivity as compared to solution-based chemistry. Oxone was shown to react with 1,2,3-trimethoxybenzene to yield predominantly 2,6-dimethoxybenzoquinone in the solid state or 2,3,4-trimethoxyphenol in solution. The difference in effective acidity of the reaction conditions was not apparently responsible for the observed selectivity. The mechanochemical method described is simple, reproducible, and gave higher yield at higher conversion of substrate compared to solution conditions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
S.L. Collom, P.T. Anastas, E.S. Beach, R.H. Crabtree, N. Hazari, T.J. Sommer,