Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271699 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
An efficient reaction protocol for the palladium-catalyzed synthesis of 2,4-diacetoxycyclopentylideneacetates by a reaction of acetic acid with 3,6-heptadienoic esters, has been developed. The process, which occurs in the presence of oxidants, represents the first example of sequential double acetoxylation-cyclization of substituted 1,4-dienes to form cyclopentane rings with oxygen functionalities at 2 and 4 carbon atoms. The use of a water/acetic acid reaction medium has also been shown to give satisfactory results.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paolo Bottarelli, Mirco Costa, Nicola Della Ca', Emanuela Fava,