Article ID Journal Published Year Pages File Type
5271746 Tetrahedron Letters 2013 4 Pages PDF
Abstract

Carboxylic acid additives have been shown to significantly improve the yield of the Pd-catalyzed intramolecular N-arylation of 2-aminopyrroles containing a 2-chlorophenylsulfonyl group at the 3-position to give a novel tricyclic ring system. Pivalic and phenylacetic acid provided the best yield enhancement, while acetic acid showed moderate enhancement. Other acids showed limited to no enhancement or even a detrimental effect on the reaction.

Graphical abstractCarboxylic acid additives have been shown to significantly improve the yield of an intramolecular Buchwald-Hartwig N-arylation reaction.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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