| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271758 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A new and preparative oxidation of silibinin has been developed to give access to two different silibinin derivatives known for their enhanced antioxidant properties. Conventional heating methods were compared with results obtained from microwave (MW) heating. The base-catalysed oxidation of silibinin under MW heating is a very efficient method for the preparation of 2,3-dehydrosilybin and a related silybin rearrangement product. This latter compound shows enhanced radical scavenging properties. Optimised conditions were used to prepare 2,3-dehydrosilybins A and B from optically pure silybins A and B. An efficient, preparative purification method was also developed to enable isolation of different products in high purity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Giovanni Di Fabio, Valeria Romanucci, Mauro De Nisco, Silvana Pedatella, Cinzia Di Marino, Armando Zarrelli,