| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271789 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32-hydroxy group. The aim was achieved by means of two regioselective Candida antarctica lipase-catalyzed steps. The structure of the new key intermediates, 24-, 32-monoacetates, and 24,32-diacetate, was established by means of an unambiguous NMR study.
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Authors
Patrizia Ferraboschi, Diego Colombo, Maria De Mieri, Paride Grisenti,