| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271852 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
We report the efficient synthesis of difluoroalkyl aryl ethers from the rearrangement of heteroaryl ketones and aldehydes, mediated by xenon difluoride and HF/pyridine in methylene chloride at room temperature. Computational analysis of difluoroalkylethers shows that there is potential to allow access to conformational space not accessible to the hydrogenated parent.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel B. Horne, Michael D. Bartberger, Matthew R. Kaller, Holger Monenschein, Wenge Zhong, Stephen A. Hitchcock,