| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271886 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
An in situ generated complex of palladium(II) and a biguanide, namely metformin, was found to be a highly efficient homogeneous catalyst for the phosphine-free Suzuki-Miyaura reaction. Significant rate acceleration of the palladium-catalyzed coupling was observed when a 1:1 mixture of ethanol/water was employed as the reaction solvent. Using this protocol, a variety of aryl halides (Cl, Br, I) were subjected to reaction with various arylboronic acids and the products were obtained in good to excellent yields under mild reaction conditions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
A. Alizadeh, M.M. Khodaei, D. Kordestani, M. Beygzadeh,