| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5271923 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
Concomitant supplementation of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid, and a DNA methyltransferase inhibitor, 5-azacytidine, to the culture medium of a plant endophytic fungus, Pestalotiopsis acaciae, dramatically altered its metabolic profiles. As a result, three novel aromatic compounds, 2â²-hydroxy-6â²-hydroxymethyl-4â²-methylphenyl-2,6-dihydroxy-3-(2-isopentenyl)benzoate (1), 4,6-dihydroxy-7-hydroxymethyl-3-methylcoumarin (2) and 4,6-dihydroxy-3,7-dimethylcoumarin (3), were isolated, along with five known polyketides, endocrocin (4), pestalotiollide B (5), pestalotiopyrone G (6), scirpyrone A (7) and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (8).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, Ikuro Abe,