Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271945 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000.
Graphical abstractA range of polymeric supports was prepared and investigated for applications in an enzyme cleavable assay.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ana Chiva, David E. Williams, Alethea B. Tabor, Helen C. Hailes,