Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271985 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
Boric acid and glycerol efficiently catalysed the one-pot, three-component Mannich reaction of aldehydes, aromatic amines and cyclic ketones in water at ambient temperature to afford the corresponding β-amino carbonyl compounds in good yields. All but one reaction proceeded with moderate 'syn' diastereoselectivity. This observation is just the reverse of the major anti diastereoselectivity obtained in most of the earlier reported procedures. The methodology is mild and efficient using minute quantities of catalyst with no side products and a very simple work-up procedure.
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Authors
Chhanda Mukhopadhyay, Arup Datta, Ray J. Butcher,