| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272014 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
Trimethylsilylcyanation of aldehydes is efficiently accomplished with a low concentration of catalyst 1 under mild conditions in acetonitrile. This protocol tolerates a variety of electron-rich, neutral, and deficient aryl, heterocyclic, and alkyl aldehydes. At the end of the reaction, catalyst 1 precipitates from solution, allowing it to be recycled three times.
Graphical abstractDimeric alumatrane 1 efficiently catalyzes this reaction at low concentrations (generally 0.5 mol %).Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven M. Raders, John G. Verkade,