Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272076 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
The 1,2,3-triazole scaffold is an important pharmacophore and a versatile, increasingly leveraged, substructure in biochemical, materials, polymer, and metal-coordinating applications. Continuing advances in 1,2,3-triazole construction, by either non-catalyzed or metal-catalyzed azide/alkyne cycloaddition, foster further creative use. The work reported here establishes a general protocol for the synthesis of 4,5-bis(trimethylsilyl)-1H-1,2,3-triazoles via thermal Huisgen cycloaddition between azides and bis(trimethylsilyl)acetylene.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ronald G. Brisbois, Alexandra M. Bergan, Aubrey J. Ellison, Percy Y. Griffin, Kent C. Hackbarth, Steven R. Larson,