pTSA-catalyzed one-pot synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in ionic liquid and neat conditions

Multi-component condensation of β-naphthol, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by p-toluenesulfonic acid has been accomplished for the synthesis of a series of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in ionic liquid([bmim]BF4) and in solvent-free media. High yields, ease of recovery, and reusable reaction medium (ionic liquid) with consistent activity makes this protocol efficient and environmentally benign.

Graphical abstractAn efficient and environmentally benign protocol for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones is described.Download full-size image