Article ID Journal Published Year Pages File Type
5272124 Tetrahedron Letters 2013 4 Pages PDF
Abstract

A simple and efficient synthesis of α-aminophosphonates has been developed via the one-pot three-component reactions of aldehydes, amines, and trialkyl phosphites. The reactions occurred rapidly at room temperature in the presence of 1 equiv of propylphosphonic anhydride (T3P®) as the condensing agent, and the α-aminophosphonate products were obtained in high yields.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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