| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272128 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
CuI facilitated three-component reaction of isatin derivatives, l-proline and terminal alkynes containing an amide or ester functional group. The multi-component reaction (MCR) afforded a faster and practical synthesis of spirooxindole derivatives. A range of novel spirooxindoles were synthesized by using this straightforward and one-pot efficient methodology. A representative compound showed significant inhibition of PDE4B enzyme in vitro and good interactions with this protein in silico.
Graphical abstractCu-mediated three-component reaction afforded novel spirooxindoles for the potential inhibition of PDE4.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shambhu Nath Singh, Sridhar Regati, Abir Kumar Paul, Mohosin Layek, Sarva Jayaprakash, K. Venkateshwara Reddy, Girdhar Singh Deora, Soumita Mukherjee, Manojit Pal,