One-pot solid phase synthesis of (E)-nitroalkenes

An efficient one-pot protocol for the synthesis of (E)-nitroalkenes by reaction of aldehydes and nitroalkanes in the presence of polymer-bound triphenylphosphine, iodine and imidazole is described. Although the reaction works with similar efficiency with triphenylphosphine and its polymer-bound version, easy removal of the unwanted polymer-bound triphenylphosphine oxide and its recovery as triphenylphosphine provide the edge for practical application of the method.

Graphical abstractAn efficient protocol for the synthesis of (E)-nitroalkene by sequential one-pot reaction of aldehyde and nitroalkane in the presence of polymer-bound triphenylphosphine, iodine, and imidazole is described. One-step synthesis of nitroalkenes without using conventional dehydrating reagents, easy purification, and excellent yield of the products are some of the major advantages of the protocol.Download full-size image