Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272172 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
A synthetic route to 1-(2,6-dihydroxyphenyl)phthalan natural products is described. It is typified by the synthesis of permethyl and monomethyl ethers (21 and 22) of pestacin (1), a 1,3-dihydroisobenzofuran natural product. The key step is hydrodeoxygenation of the corresponding isobenzofuranone 19 in 2 steps: reduction and intramolecular etherification. A route involving hydrodesulfurization of a thionophthalide to a phthalan (e.g., 8) is also reported.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raju Karmakar, Pallab Pahari, Dipakranjan Mal,