Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272246 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
We report a new method using silver benzoate instead of mercury salts as a key reagent for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles. This method allows the introduction of a large variety of substituents in the three positions. We demonstrated that we could introduce one chiral center without any loss of the optical purity. This method is compatible with at least multi-gram scale-up.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mathieu Bibian, Anne-Laure Blayo, Aline Moulin, Jean Martinez, Jean-Alain Fehrentz,