Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272279 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
Substituted 2-aminothiazole derivatives were obtained as a result of N-methylimidazole catalyzed cyclization of α-halo ketone carbonyls with ammonium thiocyanate in water-alcoholic media. The generality of the method has been demonstrated by screening a series of aromatic/heteroaromatic/aliphatic α-halo ketones, α-halo β-diketones, and α-halo β-ketoesters. The developed method is simple, mild, and general route for the preparation of diversely functionalized 2-aminothiazoles in good to moderate yields from readily available starting materials.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
H.M. Meshram, Pramod B. Thakur, B. Madhu Babu, Vikas M. Bangade,