Palladium-catalyzed C-C coupling: efficient preparation of new 5-thio-β-d-xylopyranosides as oral venous antithrombotic drugs

First examples of a Suzuki and Stille cross-coupling reaction to prepare derivatives of pyridinyl 5-thio-β-d-xylopyranosides are described. Some of these compounds are orally active in an animal model of venous thrombosis.

Graphical abstractSuzuki and Stille coupling reactions were first used to prepare derivatives of pyridinyl 5-thio-β-d-xylopyranosides.Download full-size image