| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272344 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The cis-fused hexahydroxanthene system can be obtained through a cascade cyclization initiated by Lewis acid-mediated epoxide opening and terminated by reaction with a MOM-protected phenol. Only a single diastereomer of the product was obtained with stereochemistry verified by diffraction analysis. This demonstrates the viability of this approach to natural products containing the cis-fused hexahydroxanthene skeleton, and supports preparation of more complex targets through a similar strategy.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey D. Neighbors, Joseph J. Topczewski, Dale C. Swenson, David F. Wiemer,