| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272349 | Tetrahedron Letters | 2009 | 4 Pages |
A simple and practical approach for the one-pot conversion of nitroarenes into amide derivatives has been developed. Zinc and acetic acid are utilized as a reducing agent, and acyl chloride and triethylamine are used as the acylating agent in DMF with good yield (â¼60%) of the amide. This method was applicable to manzamine A (1), where the yield of 6-cyclohexamidemanzamine A (7) was significantly improved (56%) by this approach relative to (17%) by beginning with the amine.
Graphical abstractA simple and practical approach for the one-pot conversion of nitroarenes into amide derivatives using zinc and acetic acid as a reducing agent, and acyl chloride and triethylamine as the acylating agent is described with an application to manzamine alkaloids.Download full-size image
