| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272389 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when 18F-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wioleta BorzÄcka, Iván Lavandera, Vicente Gotor,