| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272431 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a 'single pot' for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45-85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.
Graphical abstractStudies of the micelle-promoted and copper-catalyzed multicomponent Kinugasa reaction in water are reported.Download full-size image
Related Topics
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Authors
Craig S. McKay, David C. Kennedy, John Paul Pezacki,