| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272440 | Tetrahedron Letters | 2009 | 6 Pages |
Abstract
A convenient method to introduce a sulfone group to pyridines and diazines is described. This efficient method involves the conjugate addition of sodium methanesulfinate to vinyl heterocycles. This process tolerates a wide variety of functional groups and is performed in the presence of acetic or trifluoroacetic acid. A one-pot, two-step synthesis of sulfones starting from the corresponding heteroaryl halide is also described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gregory M. Schaaf, Sabuj Mukherjee, Alex G. Waterson,