| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272513 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiji Ogura, Nami Maeda, Ko Morishita, Akira Otaka,