Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272514 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Synthetic construction of fucosyl chitobiose [GlcNAcβ1â4(Fucα1â3)GlcNAc] as an allergy-associated carbohydrate epitope was accomplished from three building blocks. The trisaccharidic unit was further transformed into a carbohydrate monomer and polymerization of the glycomonomer proceeded smoothly to provide a series of glycopolymers having various carbohydrate densities. In addition to the organic syntheses, biological evaluations of the glycomonomer and the polymers were carried out and sugar-clustering effects were observed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Koji Matsuoka, Hiroki Yamaguchi, Tetsuo Koyama, Ken Hatano, Daiyo Terunuma,