Synthesis of 1-bromo-1,4-dienes via palladium-catalyzed bromoallylation of alkynes

An efficient procedure for the synthesis of a series of 1-bromo-1,4-dienes by a simple Pd-catalyzed intermolecular tandem reaction of alkynes, CuBr2, and allylic alcohol has been developed. The reaction proceeds smoothly under mild condition to give the corresponding products in good to excellent yields.

Graphical abstractAn efficient procedure for the synthesis of a series of 1-bromo-1,4-dienes by a simple Pd-catalyzed intermolecular tandem reaction of alkynes, CuX2, and allylic alcohol has been developed. The reaction proceeds smoothly under mild condition to give the corresponding products in good to excellent yields.Download full-size image