Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272630 | Tetrahedron Letters | 2013 | 8 Pages |
Abstract
In this study we report on a flexible straight forward synthesis toward novel 3,5-diaryl-(1H)-pyrazin-2-ones. Our synthetic strategy involved an acyclic di-keto derivative as key intermediate. The final pyrazin-2-one ring closure reaction was yield-optimized by using a microwave mediated procedure and ammoniumacetate as nitrogen source. Our method is a suitable alternative to palladium-catalyzed coupling reactions for the 3,5-diaryl decoration of the (1H)-pyrazin-2-one scaffold. Since the (1H)-pyrazin-2-ones is present as scaffold in a number of biologically active compounds the reported synthetic platform is a useful approach to generate a set of highly diverse 3,5-diaryl-(1H)-pyrazin-2-one compounds.
Related Topics
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Authors
Eugen Johannes, Rebecca Horbert, Joachim Schlosser, Dorian Schmidt, Christian Peifer,