Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272643 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A novel approach for the syntheses of 6a-hydroxypterocarpans is reported. Its practicality is demonstrated by the synthesis of (±)-glycinol. The main feature is an intramolecular benzoin condensation catalyzed by nucleophilic carbenes to initiate assembly of the benzopyran and establish the 6a-hydroxy center. In addition, a one-pot method was developed to form an epoxide that facilitates subsequent cyclization leading to the benzofuran and direct production of (±)-glycinol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Neha Malik, Paul Erhardt,