A simple protocol for the synthesis of triazole-linked cyclic glycopeptidomimetics: a sequential Ugi-MCR and azide-alkyne cycloaddition approach

Sequential combination of Ugi-MCR and click chemistry has been employed for the synthesis of triazole linked cyclic glycopeptidomimetics. The protocol employs Poc-amino alkyl isonitriles, sugar-1-amines, azido acids, and simple aldehydes as precursors. The dual nature of the propargyloxycarbonyl (Poc) group was explored for amine protection as well as cycloaddition with an azide. All the cyclic glycopeptidomimetics are isolated and characterized.

Graphical abstractSequential Ugi-Click chemistry approach has been employed for the synthesis of novel triazole linked cyclic glycopeptidomimetics. The dual nature of the propargyloxycarbonyl (Poc) group was utilized for the synthesis of the title compounds. All the cyclic glycopeptidomimetics are isolated in appreciable yields.Download full-size image