| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272746 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The reaction of aldehydes with N-tosyl homoallylamine in the presence of a solution of tetrafluoroboric acid-diethyl ether complex in dichloromethane at ambient temperature gave the 4-fluoropiperidines in good yields and with high cis-selectivity. This aza-Prins-type cyclization has a wide scope and the use of HBF4·OEt2 makes this procedure simple, convenient, and cost-effective for the preparation of 4-fluoropiperidines.
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Chemistry
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Authors
J.S. Yadav, B.V. Subba Reddy, K. Ramesh, G.G.K.S. Narayana Kumar, René Grée,