| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272755 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A series of quinoline-based photo-removable protecting (caging) groups were synthesized for the development of new chemical tools to photo-regulate bioactive molecules in living cells and tissues with improved properties. Compared with the recently developed 8-bromo-7-hydroxyquinolinyl (BHQ) chromophore, change of the bromine substituent to a pyridine group led to a new photo-labile group (3â²-PyHQ) with an increased water solubility, a lower self-fluorescence, and a higher photolysis efficiency. It was proposed that the replacement of a halogen group by a pyridine-like heterocycle may provide a general strategy to improve the existing photo-caging groups.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yi-Ming Li, Jing Shi, Rong Cai, Xiao-Yun Chen, Qing-Xiang Guo, Lei Liu,