| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272791 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
A novel synthesis of naproxen utilizing nitroaldol, 1,4-addition and Nef reaction is demonstrated where the desired S-enantiomer is achieved by resolution. Further to this first enantioselective 1,4-addition of Grignard reagent to nitroolefin is demonstrated to synthesize derivatives of naproxen.
Related Topics
Physical Sciences and Engineering
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Authors
Prashanth Reddy, Rakeshwar Bandichhor,